![]() ![]() Get your glow on! Holly Willoughby launches her first ever beauty kit with Beauty Pie for radiant, healthy skin - and it's a STEAL (you'll save over £80) Oprah's Senate slim down? After DECADES of weight loss battles Winfrey is in her best shape - so is it a sign she's replacing the ailing Dianne Feinstein?įamed New York restauranteur behind Italian eatery that was frequented by everyone from Beyonce to J-Lo to Sylvester Stallone dies at the age of 64 Jodie Comer and Will & Grace star Sean Hayes turn up the star wattage at Outer Critics Circle Awards in NYC Stella Maxwell sets pulses racing in a sheer black dress with buttoned detail as she walks the runway at the amfAR Cannes Gala 2023Ĭristiano Ronaldo's girlfriend Georgina Rodriguez flaunts her incredible curves in a gold sparkling gown at the Last Summer premiere in Cannes Sylvester Stallone's daughters Sophia and Sistine celebrate sister Scarlet's 21st birthday with a picnic in the parkĮnjoyed a day out on Thursday to celebrate Wiz Khalifa and Amber Rose prove they're amiable exes as they celebrate son Sebastian, 10, going to 5th grade with Wiz's girlfriend Aimee Aguilar Poppy Delevingne turns heads as she dazzles in a gold sequinned co-ord while attending the Last Summer premiere at the Cannes Film FestivalĪmelia Gray Hamlin puts on a VERY leggy display in a chic white minidress as she walks the runway at the amfAR Gala 2023 during Cannes Film Festival 'Shocked at how well it worked': Shoppers swear by these £20 teeth whitening strips that deliver a whiter smile 'after one use' (see the dramatic results here) Leggy Heidi Klum, 49, and her husband Tom Kaulitz, 33, pack on the PDA with a smooch at the amfAR Cannes gala - after her awkward wardrobe malfunction while today's poor-me pampered celebrities and Montecito moaners play the victim MAUREEN CALLAHAN: Tina Turner never asked for pity. Gwyneth Paltrow, 50, is thrilled daughter Apple, 19, is back from college adding the teen now 'bickers less' with brother Moses: 'My heart is full' about a million less than his original asking priceīridgerton's Charithra Chandran admits to feeling 'vulnerable' amid her overnight fame and says she stays 'sane' by NOT having close friends her own age in the film industry Tom Hanks prompts laughs as he delivers commencement speech to Harvard University graduates - days after THAT red carpet appearance in CannesĬarol Vorderman shows off her figure in a denim jumpsuit as she leaves Have I Got News For You studio with Ian Hislop and Steph McGovernĭean Cain finalizes the sale of his lavish Malibu mansion for $6.25M. ![]() Mark Hamill talks about his fate in Star Wars Universe and how he and Carrie Fisher had 'a connection that is special' despite having 'tumultuous relationship' Georgina Rodriguez joins ageless Andie MacDowell, Poppy Delevingne and Shanina Shaik at the premiere of the racy French drama Last Summer in Cannesĭani Dyer gives birth! Star welcomes twin girls with footballer Jarrod Bowen - a DAY after watching him score in West Ham's final home match It's not all cocktails, castles and laughter Leonardo DiCaprio spends time with 'close friend' Irina Shayk at the 76th Cannes Film Festival after celebrating Killers Of The Flower MoonĮDEN CONFIDENTIAL: Farewell to the glamorous Duchess of Manchester once attacked by a speargun Mark Labbett shows off his slimmer figure in a black T-shirt as he enjoys a romantic dinner date with new girlfriend Hayley Palmer Jessica Alves puts on a VERY busty display in a yellow skin-tight jumpsuit as she attends the Summer Is Coming Party in ChelseaĮvan Rachel Wood 'hands over primary custody of son, 9, to Jamie Bell due to safety fears after ex Marilyn Manson made threats towards child' Grantchester's Kacey Ainsworth 'splits from husband of 18 years Darren Hales and finds new love with actor Liam Tobin' ![]() You be sayin' naan naan naan naan naan! Beyoncé's crew orders an Indian takeaway backstage in Sunderland Tina Turner news LIVE: Latest updates and tributes after Queen of Rock and Roll's death aged 83 MasterChef viewers slam 'pretentious' contestant for asking judges to wear HEADPHONES and listen to 'winter sounds' while eating a dessert Rebel Wilson shows off her slimmer figure in a strapless green gown as she is joined by glamorous fiancé Ramona Agruma at the amfAR Cannes Galaĭiscover Turkey (Türkiye): Why those in the know are jetting to this beach and cultural holiday hotspot Helena Christensen is radiant alongside Alessandra Ambrosio and Jourdan Dunn on the amfAR gala 2023 runway in Cannes Alice Eve cuts an elegant figure in semi-sheer embroidered pink midi dress as she leads the stars at the DKMS Gala 2023 ![]()
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![]() ![]() Whatever nonprofit/menu option you choose to commemorate the 2021 PIT Count moment, it will be put to good use. Honestly, COVID closures have resulted in many of our recently housed clients losing all or part of their income…and no one wants the work of those clients and their case managers to be undone because someone is short on the rent. Theyre divided by spirit and subdivided into six preparations: on the rocks, shaken up, tall & cool, stirred up. It isn’t as righteous as counting in teams in the middle of the night, or as fun as assembling packs of things to give to clients, but our focus is a housing plan and ending homelessness-and rent and deposits and utilities require cash. If you would like to do something this year to mark your traditional PIT Count participation, helping with a donation to Front Steps would do the most good. Our biggest need right now is rental assistance dollars to help clients secure and keep stable housing. Our one request isn’t boots on the ground, or shopping and packing items-but it really is a Pretty Important Thing/PIT! Front Steps manages multiple programs to end homelessness, as well as the downtown shelter (the ARCH)-and we house hundreds of individuals a year from the shelter/streets. The city is the cultural and economic center of the AustinRound. With no PIT count in 2021 for safety reasons, we are being given a chance to present an optional way to help this year. As of 2021, Austin had an estimated population of 964,177, up from 961,855 at the 2020 census. The 102 East Market Street restaurant’s opening day is Saturday, May 27. Texas barbecue pop-up Barbs B Q is opening its very exciting smoked meats restaurant this month in Lockhart. The time and effort donated during those annual cold, dark nights supports the work of the many nonprofits working to end homelessness in our community. Want a minute-by-minute forecast for Austin, TX MSN Weather tracks it all, from precipitation predictions to severe weather warnings, air quality updates. 2 days ago &0183 &32 The women of Barbs B Q are smoking up lime-zested ribs and Mexican spiced briskets in May. You can hang out in the bar area inside, or head outside to the expansive backyard with twinkling lights. If your favorite food-serving bar isn't listed below, let Eater know through the tipline, comments, or start a forum thread.PIT Count Volunteers do important work every year in January. More bar than restaurant, Weather Up serves some of the best cocktails in Austin, and is perfect for a ladies’ night or other group outing. It gets much hotter on an average of 29 days a year, with temperatures. Whether you’re looking for white-tablecloth-worthy cuisine with Hopfield’s or simply one of the best sandwiches ever invented at Waller Creek Pub, any of these bars is an excellent spot to linger for hours while eating and drinking the night away.įor more booze fun, check out Eater's guide to essential cocktail bars, the freshest drinking spots in town, and exemplary places for beer.Įverything below is unranked. Most summer days in Austin heat up to a least 90 degrees. The ABGB proudly names the local farms it works with to create fresh fare, Easy Tiger is committed to making everything in-house. Paired with thoughtful cocktails are full-on meals from Drink.Well and The Townsend. At Lenoir, we celebrate seasonal Texas ingredients, we cook for the season (and the weather - hot) and we serve it with fantastic beer and wine from great. ![]() In addition to A+ alcoholic offerings, the places on this list also get the details right with the dishes. This leads to Eater's guide to the best bars serving excellent food. Though many bars offer stellar food trucks, there are others that offer chefs commanding full kitchens, producing food on par with top restaurants. Eating at a bar does not have to mean you have to suffer through a menu created entirely in a deep fryer. ![]() ![]() ![]()
![]() Early in his career, Callum worked at the Ford-owned design house Carrozzeria Ghia in Turin. “I think have respected art and design probably longer than any other country,” says Callum, vice president of design at Ford. ![]() The culture is also permeated by a reverence for aesthetics. “Just holding a pencil in this country makes you feel more creative,” says Bangle, BMW’s former design chief.įioravanti\’s berlinetta boxer. Directly translated, it means “to make a good figure” in practice, it’s more like, “make an effort to be noticed” or “nail the first impression.” This is the nation that took something as universal as an evening stroll and elevated it to la passeggiata, a daily ritual of well-dressed, leisurely flaunting and flirting. Style is part of the bedrock of Italian culture. “For me,” says Mitja Borkert, current head of Lamborghini design, “everything that we do relates to the design DNA that the Countach gave us.” It wasn’t just Lamborghinis: Gandini penned the first BMW 5-series and the Renault 5 Supercinq, too. Hard to believe, but the totem of 1980s angular excess debuted in 1971, just five years after the voluptuous Miura. It inspired the production Lancia Stratos, a slightly more practical automobile that dominated rally racing. Four years later, Gandini showed the most radical concept car in history: the Lancia Stratos Zero, a sci-fi wedge. It was the first road car with a mid-mounted V-12 engine, the original supercar. The next year, he rocked the world with the debut of the Lamborghini Miura. Gandini joined Bertone in 1965, after Giugiaro left. “He showed the world that a mass-market product can have attractive and iconic design,” says Ralph Gilles, head of design at Fiat Chrysler Automobiles. He styled normal cars, too-he has called the Mk1 Volkswagen Golf of 1974 his best and most important design-in addition to Nikon cameras, Seiko watches, and Beretta firearms. He penned outrageous concept cars, such as the Bizzarrini Manta and Porsche Tapiro, exotics like the De Tomaso Mangusta and the Maserati Bora, and icons like the Esprit, the BMW M1, and the DeLorean DMC-12. Giugiaro apprenticed at Fiat, passed through Bertone and Ghia, and in 1968, founded his own design firm, Italdesign. “In general, engineers just don’t do creative, beautiful automobiles. “I’m still surprised that Fioravanti was an engineer,” says Welburn, former head of global design at General Motors. A partial list: the 1967 Dino 206 GT, the 1968 365 GTB4 Daytona, the 1975 308 GTB, the 288 GTO, the Testarossa, and the F40. ![]() Name a memorable Dino or Ferrari of the past 50 years and you’re likely to land on a Fioravanti design. He immediately started designing amazing machines. He trained as a mechanical engineer, focused on aerodynamics, and joined Pininfarina in 1964, straight out of school. ullstein bild Dtl.įioravanti is responsible for an entire generation of iconic Ferraris. How did this tiny triangle of Italian soil give rise to three titans of modern design? To find out, we asked the designers who’ve shaped some of our favorite modern sports cars, people like Chris Bangle, Ed Welburn, Ralph Gilles, Moray Callum, and more. It’s enough to make you wonder what was in the water. If your favorite car has two seats, a midship engine, and a profile like a doorstop, it likely owes its existence to one of these three men. Lamborghini Countach? Gandini’s gift to the world of motoring and the bedroom-poster industry. Lotus Esprit? A Giugiaro design so enduring, every subsequent face-lift and overhaul across 28 years of production maintained the same shape and style. Ferrari 512 BB? A Fioravanti masterpiece that defined that automaker’s golden era. This story originally appeared in the July 2019 issue of Road ![]() ![]() But more to the point, Boot Camp is different from Virtual PC. Well, it’s not as if Intel-based Mac owners can run Virtual PC now-the emulation software isn’t compatible with the Intel-powered Mac mini, iMac, and MacBook Pro. However, if you hope to run those applications natively in the Mac OS, you may want to hold off as it’s highly unlikely Adobe is going to provide a free-crossgrade from the Windows versions of its tool to the Universal Binary version that runs under Mac OS X. So you may well see better performance running them natively under Windows than using OS X’s Rosetta emulation technology. Those programs will run at the full speed of the native Windows versions. Since we’re going to have to wait some time for Adobe’s products to run natively on Intel-based Macs, could I get better performance if I buy the Windows versions now and run them on a Mac using XP? Windows and Office are one-machine licenses, so you’ll have to purchase additional copies. Some programs allow for multiple installs, but you’ll have to check the license agreement. If the license agreement for the software restricts it to one machine only, then no. I’ve already used my Windows and Office registration numbers on my PC. Will that work with the Windows-OS X dual-boot systems? On dual-boot OS 9/OS X systems, I could hold down the X key on restart to boot into OS X. Or if you prefer, at boot time, you can just hold down the Option key to get a drive-picking utility that will let you select which volume you want to start up from. From Windows, you can use the Startup Disk Control Panel that Boot Camp installs. From Mac OS X, you can use the Startup Disk preference pane, which now displays Windows disks alongside Mac OS X volumes. But how do I set which OS I’m booting into? ![]() So I don’t have to choose which operating system to use each time I boot. Boot Camp is better than that hack on all counts. And you need to have a Windows PC in order to create a modified Windows installation disc. The hack didn’t include any Windows drivers for Mac hardware, so Macs that used the hack to install Windows XP generally didn’t work very well. You had to choose which operating system you wanted to use every time you rebooted. However, installing that hack took quite a bit more effort than Boot Camp. Got Windows to install on Intel-based Macs a few weeks before Boot Camp’s released. You’re referring to the two enterprising hackers who Is there a way to create a SP2 disc with what I have? OK, I understand that Boot Camp requires a version of XP that includes Service Pack 2, but I only have an original XP disc. You can’t buy an “upgrade” copy, because you’re not upgrading from a previous version of Windows. (And yes, we specifically mean SP2-when we tried installing SP1 during one of our tests, it didn’t work at all.) You can’t just copy the version of Windows that came with any old PC, because it can’t be installed on any system other than the one it came with. No, you need to have your own full version of Windows XP Service Pack 2. Wait-I thought all I had to do was install Boot Camp and then I’d be running Windows. ![]() When the lengthy Windows installation process concludes, you insert the CD-ROM that the Boot Camp Assistant burned, which installs the appropriate Windows drivers, as well as a Windows utility (much like the Startup Disk preference pane) that lets you choose your startup volume. Once the Boot Camp Assistant does its job, your Mac reboots and-thanks to a recent firmware update-you can insert your Windows XP installation CD and it will be recognized as a bootable volume. ![]() ![]() ![]() It branched at the top, and had a far from linear cable attached to it. It wasn't feeding directly into the ground giving it a straight, clean path like a normal lightning rod would. The antenna was not a lightning rod, it was a conduit/conductor. If it strikes a big metal antenna that's connected to a building, it will break some stuff. When lightning strikes a tree, the whole thing explodes and or catches fire. It's not a clean energy transfer by any means. Lightning is incredibly volatile, for lack of a better term. ![]() If it's got enough power to arc from the sky to the ground, it's going to arc from a cable to a clock that's a foot for two away. Even without an explosion, the lightning is so powerful and erratic that it would arc to every piece of metal even close to it. Even if the cable were to divert the lightning away from the clock, there would be an explosion. It's not a small amount of energy by any stretch of the imagination. The existing answers make very valid points, but may also be overthinking it. So based on the resistance within the time machine this could actually mean that most - and not just a bit - of the lightning's power interacts with the clock (read: destroys it). Before the Flux Capacitor could act as some kind of current limiter, which is no longer possible. However, it changes a lot for the clock! Due to the clock now being parallel to the rest of the circuit, there'll be a most likely significant higher voltage and current involved now. Let's have a look at the updated circuit:Īs you can see, this changes nothing for Doc. So it seems like Doc intentionally used the hands of the clock as some kind of cable relief (otherwise he would have unplugged it when he attempted to slide down). He's like a bird sitting on a power line.Įdit: After watching the scene over and over again (after reading Valorum's answer), I noticed that you can actually see that the top end of that cable is connected to another cable, which goes straight up to the antenna. So the actual (simplified) circuit looks most likely like this:Īlso note that despite Doc holding the cable, he's essentially short-circuited out (meaning there's essentially almost no potential difference between his hand and therefore next to no energy flowing through him), which allows him to survive this (at least on a Hollywood level of physics being applied, considering the halo around the cable, etc.). Worst case it could have been that the clock provides a lower resistance towards ground, which would have caused most (if not all) of the electricity not going through the cable and time machine. ![]() If Doc wanted to protect the clock, he'd most likely been able to attach the cable to the flag pole/antenna instead, but it's also likely that this might have screwed the whole circuit, since we don't know the actual resistance of the clock compared to the cable and flux capacitor. The electricity then continues through the clock, over the hands and then the cable.Īs such the whole energy is not diverted from the clock, but rather pulled through it directly. ![]() If you stop the video linked by Paulie at the right moment, you'll see the lightning striking the highest point of the building (which actually makes sense):Īs you see, the lightning strikes that small antenna or flag pole on top, not the pointers of the clock. However, the wrong assumption is that the clock is not part of the circuit, because it actually is! The power flows through the cable, that's correct. ![]() ![]() ![]() ![]() Must i look out for another drive manufacturer? In my computers are running 6 WD EADS 2 TB Drives (4 in the MyBooks) - ok not a viedeo studio, but for a single person not the least. Spent 740 Euro for two 4TB Drives advertised as the choice of the professionals, i’m dissapointed by the attitude WD is showing to me - the custumer. Perhaps this DLG would run on my parallels - but there is not enough room on my disks to back up 3.95 TB of *.mkv’s - that’s why i bought a 4 TB drive !!! This action is taken at first and last by me - for several times - no difference. Adium is great with it).Īnyway - i had to agree with steelduck: WD must say something about the state of support to those drives.Īnd the people of WD must state it in the near future, or everybody will think that WD is not interested in the customers who spend a lot of money for a “high performance, three interface, best option for power video user” drive. Thats not the right way (and don’t take me wrong - nothing against growl. I had to take growl to know where my MacDrive is sick?!?īut if there is a so called drive manager, why i must install a third party software to know something about my drive? Which is not in the situation to send a correct message to the system it is design for. It’s a poor thing that WD isn’t able to give away a MacDrive (and WD is called it a Mac Drive - not me), Whether it is a 2 or 4 TB drive - or i’m wrong? My drive is - like the one from steelduck - a 4 TB.īut i see that the suggestions given by you will take no more effect, ![]() ![]() Regardless of the order in which you unlock Seals and Potions, the cost will increase as shown below. There is no limit to how many Seals or Potions can be unlocked within a given time period, if you have the required materials to sacrifice to the Altar. For example, if you want to unlock Seal B or C, Seal A must already be unlocked. To unlock a Seal, the one preceding it must be unlocked first (this does not apply to Seals R, S, and T because of how they’re positioned within the Altar). In addition to receiving the power after unlocking, you’ll notice the generic text previously displayed has been swapped with a small story scrap about Sanctuary’s tumultuous past. Players must gather materials listed in the Altar of Rites menu and sacrifice them in order to gain a Seal or Potion’s power. Unlocking Seals and Potions will be no easy feat, especially after multiple sacrifices-you’ll find yourself rummaging across Sanctuary slaying scores of demons hellbent on preventing you from acquiring the Altar of Rites’ full power. All Seals and Potions can be unlocked by players and the powers apply to all your characters-these powers last for the entirety of Season 28. Once a Seal or Legendary Potion Power is unlocked, you’ll immediately receive that Seal or Potion’s power and will have the ability to unlock connected Seals or Potions once you have the required materials. How Seals and Potions WorkĪs you can see, after unlocking the first Seal, the order in which you unlock additional Seals and obtain their powers is entirely up to you and which powers align with your character’s build the most. To compensate for the power decrease, we buffed several damage Seals elsewhere in the tree. We have removed all pylons from the final potion power and replaced them with a 16-second Dimensional Power pylon. So, we made some adjustments to keep the power level high, while having your character's progression still matter. When you drink your health potion, gain a random shrine or the Dimensional Power pylon effect.ĪD When a primal item drops, a second random primal item drops as well.ĭeveloper's Note: We wanted the seasonal theme to be powerful and rewarding, but Conduit pylon completely broke the game. When you drink your health potion, all enemies within 25 yards deal 25% less damage. Pets pick up and salvage common, magic, and rare items.ĭouble the chance to find a legendary item purchased from Kadala.ĪA When you drink your health potion, you manifest one of three runic circles on the ground that grant increased damage, increased cooldown reduction, or increased resource cost reduction. Gain immunity to crowd-controlling effects.Įlite packs drop one additional progress orb. Reduces the damage taken from elites by 25%. Progress orbs from Nephalem and Greater Rifts are automatically picked up within 60 yards. Increases your highest elemental skill damage bonus by 10%.ĭouble the amount of Death's Breaths that drop.Ĭritical hits grant resource: Mana: 15, Hatred: 5, Wrath: 5, Arcane Power: 3, Fury: 3, Spirit: 5, Essence: 5.ĭouble the amount of Bounty Caches that drop from completing bounties. Picking up Health Globes grants a shield for 5% of your maximum health for 7 seconds. Pools of Reflection last for the entire Season and are not removed by death. Your Kill Streak timer duration and reward bonus are doubled. ![]() Take a moment to familiarize yourself with the elements below. Upon arrival at the Altar of Rites, players will see 26 icons called Seals and three Legendary Potion Powers. You can begin interacting with the Altar of Rites at Level one. Home to power thought to be extinct from Sanctuary, the Altar of Rites will bestow these mystic forces upon worthy Nephalem. Shaken to their core by the eldritch aroma of the monolith, they’ve enlisted the assistance of brave Nephalem willing to investigate this sinister discovery that was once left to time-the Altar of Rites. Amid a mining expedition, citizens hailing from New Tristram stumbled across an ominous Altar carved from an archaic material bearing cryptic markings. ![]() Season 28: Rites of Sanctuaryįor Season 28, Rites of Sanctuary, we’re travelling deep into the mysterious ruins of the Festering Woods. ![]() Note: All changes apply to all versions of Diablo III, including PlayStation 4, PlayStation 5, Xbox One, Xbox Series X|S, Nintendo Switch, and PC unless otherwise indicated. These are all the changes coming in version 2.7.5, when it goes live on 21 February at 11:30 a.m. ![]() Below are the full patch notes as provided by Blizzard. ![]() ![]() When you really feel like celebrating, you need to dance. When you need a little extra in your “aww yeah” Send the team some love.įor when the default :100: just isn’t good enough to convey how you feel A glowing review from a client was received. Someone went above and beyond in their work. Let’s start with the reaction emoji that we most like to use. Celebrate Good Times, Come On! (It’s a Celebration) Now you can create animated emoji yourself–You’re welcome. This is your monster mega list of 100-ish custom emoji your company Slack needs. This is no simple list of Twelve Must-Have Slackmoji. Slack Emoji Lists Aren’t Hard to Findīut be warned: this is no basic list of Five Emoji for Coders. They can convey your mood or reaction faster and more succinctly than text can. They say Slack lets you “bring your whole self to work.” Emoji helps you be your whole self with a simple and silent click of the mouse. And, we’ve managed to add 514 custom emoji to our Slack team. ![]() The solutions we deploy are lean and innovative. And Slack emoji just helps us with our game. But, we get a lot of work done at Revelry. So the fact that you can create animated emoji AND upload no limit of custom emoji to round out your Slack conversations might not help in that regard. ̩̩͙*ೃ˚.˚ଘo(∗ ❛ั ᵕ ❛ั )੭່˙ᴵˈ ˡˡ ᵖʳᵒᵗᵉᶜᵗ ʸᵒᵘ ˚.Slack might get a lot of… well, slack for distracting people who are trying to get work done.Mix and match the sparkles with various types of text fonts and kaomoji! See also the master list for more borders and dividers! They’re great to use on social media posts, like Tumblr, Amino or Twitter. You can also put your text in the center as a headline divider. Use these glitters for dividing posts or long texts. However they work fine in Firefox and most apps like Instagram, Discord and Slack. ![]() Nᴏᴛᴇ: Some of these glittery splitters may unfortunately not show up properly in Chrome browsers due to how Chrome reads Unicode characters. You’ve probably seen these decorative stars and sparkles before! I love how they’re actually on just one line but they still look like they take up multiple lines! Try using them to make some cool bios and blog posts. Wouldn’t it be nice to go out camping in the great outdoors and stargaze? Feel the wind brush your cheek and listen to the trees being swayed by the wind? Here’s some sparkly designs to encapsulate that mood ~ ヾ๑ˊᵕˋ๑◞♡ If you’re into things that lie beyond planet earth then these combinations of stars and moons will be a perfect match for you! These cool and girly glitters come with lots of flowers, hearts, bows and ribbons! These decorations can suit all sorts of happy and soft aesthetic moods ~ ✨(◕▿◕✿) See Also: Special Fonts and Circle Numbers Cute Sparkles Use the star symbols to show excitement, moons for deep feelings and dreaming, hearts for love and romance, flowers for nature and and musical notes for dancing and singing! You can even combine these patterns to display your own mood. ![]()
![]() ![]() A widely accepted measure of beta-cell function is the disposition index (DI), that is, the product of insulin sensitivity and insulin secretion 15. As the normal physiological response to decreased insulin sensitivity is an increase in insulin secretion, the assessment of beta-cell function should incorporate both measures (that is, insulin sensitivity and secretion) 15. The inconsistencies could also be related to a failure to correct for prevailing insulin sensitivity when assessing beta-cell function. Inconsistent findings may relate to differences in concomitant pharmacological therapy, the participants’ pretrial insulin secretory capacity, or differences in exercise modality, intensity and/or volume 10, 11, 12, 13, 14. Overall, adding an exercise intervention to diet-induced weight loss improves glucose-stimulated beta-cell function in people with newly diagnosed T2D in an exercise dose-dependent manner (NCT03769883).Īs the progressive deterioration of normal beta-cell function is regarded as a determining factor for the onset and subsequent progression of T2D, re-establishing beta-cell function is considered pivotal to improving the pathogenesis of T2D 1.Īlthough a substantial diet-induced weight loss is consistent with improved beta-cell function 2, 3, 4, the effects of exercise on beta-cell function in T2D are not well understood 5, 6, 7, 8, 9. We report three serious adverse events (two in the control group and one in the diet control group), as well as adverse events in two participants in the diet control group, and five participants each in the moderate and high exercise dose groups. Here, we carried out a four-armed randomized trial with a total of 82 persons (35% females, mean age (s.d.) of 58.2 years (9.8)) with newly diagnosed T2D ( 0.001 for trend). ![]() It is unknown if adding exercise to diet-induced weight loss improves beta-cell function and if exercise volume is important for improving beta-cell function in this context. Mathias Ried-Larsen ORCID: /0000-0002-8388-5291 1, 8ĭiet-induced weight loss is associated with improved beta-cell function in people with type 2 diabetes (T2D) with remaining secretory capacity. ![]() Effects of different doses of exercise and diet-induced weight loss on beta-cell function in type 2 diabetes (DOSE-EX): a randomized clinical trial ![]() |
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